Image from Patrick Wanis Ph.D.
Decided it may be best to put this essay next in my COVID series. I had NEVER even heard of this terminology, “disruptive technology” until looking for sources just for this COVID series. It is actually disconcerting the amount of “disruption” mRNA technology may be in the future and already now is causing.
One of the first papers I found as a source was Karl-Josef Kallen and Andreas Theß paper, “A development that may evolve into a revolution in medicine: mRNA as the basis for novel, nucleotide-based vaccines and drugs”. It was in the Title and the First paragraph of their paper that I learned of “disruptive technologies”. With the possibility to do more at reduced costs, mRNA vaccination technology would constitute a truly disruptive technology [Christensen, 1997], from “The innovator’s dilemma: when new technologies cause great firms to fail (management of innovation and change).” Watertown, MA: Harvard Business Review Press
So, there it is in the Title, with little fanfare, “Revolutions in medicine”. Whatever they want to call it, gene therapy is pretty accurate, although gene manipulation is being done in countless ways and so the term “gene therapy” is easily misunderstood. Each of those countless ways have financial investors. Many of these Biologic Scientists are sponsored by partial State funding. Each individual mRNA technology has the potential for a Billion dollar drug and always the possibility of causing great (pharmaceutical) firms to fail.
This Revolution is long term and involving multiple trillions of dollars. What is the history of these genetic modifications technologies. Honestly, I’m tired, will get paid nothing and who knows, maybe put my life on the line, so you can research opposition to this essay on your own. Anyways, like my previous essay, I really only needed one or two sources. The referenced Kallen paper describes the history of these types of gene therapy modification.
Where’s the beef?
Initially double stranded DNA had been a major focus for vaccine and medication delivery systems from the 1990’s, but concerns of gene insertional mutations led to more research into single stranded RNA research. One company, ModeRNA, put it right in their name and spent 15+ years working on mRNA technologies for numerous “disruptive” gene therapy technologies. (Each potential drug requires some tweaking of technologies)
So this 3rd booster may be the exact same “vaccine” without modifications for mutations like delta, but in the FUTURE when these medication technologies are perfected, they predict fast and lucrative updates specifically for the mutating virus.
Last week the FDA and “the Fauc” decided the vaccine is “safe” and effective for your children 5-11 year olds. They publicly stated the 1/3 dose would be proper for this age group. That age range is probably 40lbs to 200lbs. Some real “science” in that dosing.
Robert Malone M.D., is considered the “creator” of the initial basic mRNA technology, although you will hear a denigrating, concerted and organized “hit squad” saying he didn’t create mRNA vaccines. He has weighed in extensively about his concerns regarding “full speed ahead” and selectively following science as a dangerous precedent. Dr. Malone was involved with transferring emphasis on dangerous nuclear DNA materials, to mitochondrial RNA as a mechanism of organism specific antigen production in human cells. Dr. Malone may actually be the creator of this “disruptive” technology, so why don’t they want you to know it? It appears because a thing called Conflict of Interests.
At this point we run into another new “disruptive” technology that has emerged as a required component in many of these gene therapy drug delivery systems. The mRNA, when exposed to mechanical and chemical environments it deactivates the medication, thereby requiring another nanotechnology. For this essay we will stick with “Lipid Nanotechnology” described in Samaneh Mashaghi, Tayebeh Jadidi, [...], and Alireza Mashaghi paper. In these applications, nano-devices typically interface with the plasma membrane of cells. On the other hand, naturally occurring nanostructures in biology have been a source of inspiration for new nanotechnological designs and hybrid nanostructures made of biological and non-biological, organic and inorganic building blocks. Lipids, with their amphiphilicity, diversity of head and tail chemistry, and antifouling properties that block nonspecific binding to lipid-coated surfaces, provide a powerful toolbox for nanotechnology.
Other controversial technology vying to be a “disruptive technology” in many areas is Carbon Graphene nanoparticles. They are being experimented on as being that vaccine protection against mechanical and chemical degradation.
Put up your dukes…
If “disruptive technologies” can cause Great Firms to fail, and these firms are admittedly positioning themselves and investors for Billions and Billions globally, maybe even on just one specific cancer medication or therapy. Could these massive financial interest cloud sound medical judgement even to the point of restricting therapeutic medications, to achieve goals.
How many of these mRNA medications and Nanotechnologies are they touting now have gone through the entire rigorous FDA testing process to actual full approval? Not many, if ANY. Would these vaccines (and early experimental gene drugs) have extensive warnings if advertised on Cable? Would there be strict prescription information on potential Co-morbidities? Could a massive program of mRNA technology experimentation using current COVID vaccines also be used as a mechanism to bypass STANDARD scientific procedure regarding these other Novel potentially dangerous and unknown “disruptive technology” medications?
“Who would want to stop cancer drug development”, not me, but that will be used as a narrative. Just as being called a hypocrite for taking a vaccine, when never opposimg vaccines, even with known complications. I did receive the J&J vaccine and recommended it to people who feared Novel untested mRNA “vaccines”.
Exactly who benefits from the positioning and possibly the bypassing of traditional safety precautions for widespread potentially human genome mutating experimental drugs. I will attempt to research that question and answer in my next COVID blog. Let’s see where these Lipid Nanoparticles go, after vaccine injection into arm muscle. Dr. Malone recommended a paper we will review in my next blog post.
ModeRNA’s Tal Zak’s explains his excitement for gene therapy, when in 2017 he gave a TED talk. Without knowing he shed light on the degree of “disruptive” technology mRNA is. ModeRNA has literally hundreds of Gene manipulation drugs stalled in the required FDA staged safety and efficacy tests. Imagine the Conflict of interest in pushing COVID vaccines as pipeline to approval of Billions in drug therapies.
I am all for these advances, but many questions need public answers and “breakthrough” contagions with Cancer treatments, along with “Insertional mutations” are two areas of my concern.
Ted Talk “The disease-eradicating potential of gene editing“
Misdirection..
Anyone interested should follow the TED link and below should be links to dozens of excited scientists and entrepreneurs. Each with their own bias and conflicts of interests.
Some seem excited to play God and will essentially denigrate those who don’t entirely embrace whatever technology they are associated with…
What used to be land grabbing is now Technology grabbing. Crypto is the primary disruptive technology. mRNA may just be a close 2nd. Both will kill off old money and create new money only to become eventual old money. Ahhh…the old expand and eventual collapse of the universe. Expansion and eventual collapse of empires (particularly democracy) as stated so well by Alexander Fraser Tytler. It can be said that a human life expectancy trajectory is more of the same expansion and eventual collapse. We traject away from wearing diapers until the eventual collapse and return hurtle toward wearing diapers again if we are not so lucky as to pass in our sleep somewhere in between.