Just what is the history of vaccines…
…are there different types available
Wellcome Images
Although getting on in age and retired from my Medical practice, I still find myself following and studying advances in medicine and science. I find joy in reading and seeing Human advances and creation in God’s World. It’s what we are supposed to do. Recently there has been a paradigm shift in Medical Practice with “public health” concerns superseding sound medical practice.
Studying the history of mankind, as an anthropology minor and with more recent developments in science and medicine, I was curious about the history of Vaccines. In our last blog we learned about viruses. In this essay I want to understand the history and science of vaccines. I would like to know the different types of vaccines and how they are being planned on use. The science and unlimited potential also raises concerns regarding “conflicts of interests” by involved scientist and physicians.
So there are the archaic early vaccines and that progressed to inactive antigen particle vaccines and now the logical extension would be into live, self replicating vaccines. These vaccines can be specifically “tuned” by genetic manipulation and seem to have unlimited potentials.
Are there different complications and considerations with each vaccine type available and how has the science changed over last year, with additional data from around the World. Those seemed to be good questions. For me, developing a rational and LEGAL “public health” plan for Pandemics, that guarantees protection of Constitutional Rights is important. This Federal control over even just the questions and discussions, let alone this blackout on current follow up data on personal health care issues, can NEVER be handled like this again. Alas, this essay is only covering the history of vaccines.
A. Sylvester 1861
So I started to research “sources” on questions involving viruses and vaccines, as the only argument against personal knowledge now is to demand “sources”. Attorneys, Bureaucrats and the Woke are ALL practicing medicine without licenses on every media outlet and demanding censorship from actual physicians and Scientists.
God must have directed me toward this exceptionally comprehensive scientific paper on novel (new) “vaccines”. The paper was published in Therapeutic Advances in Vaccines in 2013:
“A development that may evolve into a revolution in medicine: mRNA as the basis for novel, nucleotide-based vaccines and drugs”, authored by Karl-Josef Kallen and Andreas Theß.1
This is a most comprehensive discussion on the history, current and future uses and mechanisms of vaccines, frankly with well over 100 footnotes. Except for cross checking the footnote topics, little other research will be needed for this series. I would recommend this read to any medical professional or interested scientist.
Our bodies and all living creatures are constructed of the same things. Most Americans growing up have seen a Periodic Table chart. This small chart shows ALL the building blocks of our physical existence.
That’s it. There they are. Look, there’s a familiar name at #3, Lithium. Now that’s an important substance moving forward with the Utopian electric car world, plus it can help stabilize my mood a bit. Maybe a future series on “National Monuments” and the pilfering of American Citizens natural resources would be interesting.
That carbon at #6 is the big deal. Humanity is a carbon based existence and we will see advances in Carbon use that will be miraculous in the VERY near future. So this chart isn’t just lifeforms, but almost everything in our known existence. Scientists love to make new particles for 0.00000001 second and give it a name. Wigonium at #110. From these molecules, chemicals are formed and from those, lifeforms and drugs. Biochemistry in college was a difficult course, demonstrated by me taking 3 different classes, but it can be explained pretty simply. Building blocks, scissors and glues.
One developing technology using Carbon is nanotechnology, where the use of carbon based Graphene nanobot like molecules can form and reform structures (like magnetic ball cube games, but on their own). Future applications of nanotechnology is unlimited, but they have been mostly unexplored and not significantly tested when used in medicines. One Carbon molecule thick structures are possible.
Biochemistry in early medical use was mostly in medication developments, until more recently with gene therapy on living reproducing structures. Previously vaccines were mostly biochemically manipulated non-living enzyme like chemical compounds. They add or remove the molecules using chemicals to create new drugs and other substances. All the attachments are bonds to break or add more chemicals on with “scissors and glues”.
Early Inoculations
There are historic records from India and China that describe early smallpox treatments. The people used a method that began with grinding up smallpox scabs. This ground up matter was then blown into healthy people’s nostrils. Another technique was to scratch a smallpox sore, and then scratch it into a healthy person’s skin. Called “variolation,” it was also practiced in Turkey, Africa, the Americas, and Europe. In Turkey, practitioners would expose people to a less serious form of smallpox by making incisions into healthy people’s skin. They would then inoculate it with pus from smallpox sores. Some researchers believe these practices were employed as far back as 200 BCE.2
This is interesting, as it is one method apparently NOT considered by Physicans and Scientist now. Could we use inoculations on children with the basic initial COVID-19 virus, as it had little to no detrimental effects on healthy children and natural immunity is now showing better effectiveness against COVID mutations than these first generation mRNA vaccines in an article published on Israeli studies at News Rescue.5
The first primitive “modern vaccine” was given by Edward Jenner who was born in Berkeley, Gloucestershire, England, in 1749, where he used pus from cowpox to infect a child. The child showed some sickness, then recovered. The vaccine worked because Small pox and Cow pox are in the same family.
In May of 1980, the World Health Assembly announced that smallpox had been eradicated from the world. They then recommended that all countries stop vaccinating for the disease. Don’t expect that with these current COVID variants with their genetically coded high mutation rates. By the mid 90’s significant investigation and research into DNA virus “vaccines” was being performed. The article explains about the new exciting developments in mRNA medications, that appear to be replacing the earlier DNA based attempts.
So vaccines stimulate antibodies that fight off infection. Different types of Antigens (substances that induce antibodies and the immune system) exist, examples include live germs versus inanimate substances like pollen. Modern vaccines have typically been inactive portions of antigen that doesn’t cause disease, but stimulates your immune system. The immune system may be a good topic that questions would be interesting in the future. In the “new” mRNA “vaccines” a chimeric molecule is often used.
Chimeric means “a hybrid of more than one animals” where two different sets of genetic code were split and combined into one. The scientist believe that mitochondrial RNA is safer to work with than initial DNA viruses as there is less chance on “insertional mutations”. They are using enzymes and agents to split genetic code specifically at a point and then reattach a portion from another nucleoid genetic material at that same specific point. The COVID spike protein that we hear a lot about is a small portion of the COVID genome.
The “spike protein” genes are split off the COVID genome and then modified to allow the new “vaccine” antigen spike protein to reproduce more spike proteins IN the Vaccine. Major advances in Cancer therapies will use Chimeric “vaccines” essentially “tuned” to your Cancer. This will be a paradigm shift in medications. But caution should be used as significant risks are reviewed in the article.
The Kallen paper then goes into every aspect of mRNA medication information, including the dangerous possiblity of gene mutation integration (where the altered nucleoid incorporates into the human host cell DNA), to a variety of other potential concern. Immune system suppression seemed to be an important factor in this 2013 paper and recently Pfizer finally expressed concerns about a 3rd booster being required so quickly without data on immune suppression being produced almost a year into this “Novel” vaccine experiment.
So we learned that “vaccines” have been around for apparently 2 thousand years, are made from the building blocks of life and the molecules of the RNA or DNA strand. Early vaccines were weakened diseases, followed with inactive “dead” vaccine and we are now on the brink of widespread use of mRNA Live medication treatments.
This would include types of gene therapy in different forms, where modified lifeforms (symbiotic) produce missing enzymes found in some diseases. An example would be insulin producing “nano” life forms.
The first mRNA trial included 15 patients with melanoma stage III or IV in 20083. More human trials were performed in 2011. Kallen’s conclusion, “Impressive preclinical results have been achieved with mRNA-based vaccines in fields as diverse as oncology, infectious diseases, and allergy. The first clinical studies in oncology suggest that it is possible to translate these preclinical results to humans. mRNA-based vaccines can be produced at low costs in a highly flexible and scalable production process and would constitute a revolutionary, disruptive technology in vaccinology.”
Wait. Are there both types of vaccines available now for COVID? The answer is YES.
There are both the newly developing use of the living type mRNA vaccines from a number of pharmaceutical companies, as well as the older inactive technology using inactive portion of virus and in the Johnson and Johnson Jenssen COVID vaccine using Viral DNA. It only seems to be a logical question. “Doctor is one of these vaccine types available safer for me?”
Keep an eye out for “disruptive technologies” in my “Are there Conflicts of Interests in COVID politics?” upcoming essay.
My only planned photographic Art…
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3991152/
https://www.worldatlas.com/articles/when-was-the-first-vaccine-created.html
Very, very interesting...and well done.
Excited to receive follow up wig-blog.